Professor
(802) 735-2615
stefan.balaz@novimedspecialistclinic.com
Dr. Balaz’s research is oriented towards the development of experimental and computational methods for determining drug disposition and receptor binding. In disposition, his lab performs experimental measurements using (1) surrogate phases to find structural determinants of transbilayer transport rates and accumulation in membranes and triglyceride phases, (2)与常见的人类蛋白质结合，如白蛋白和细胞外基质成分. The data is used to develop structure-based models for predicting the volume of distribution and other pharmacokinetic characteristics. 这项工作的主要目标之一是找到为有限分布量身定制药物结构的方法, 从而降低药物的细胞毒性，例如用于治疗某些癌症或关节炎的药物.
Associate Professor
(518) 694-7387
richard.dearborn@novimedspecialistclinic.com
Dr. Dearborn’s research focuses on development neurobiology in the fruit fly (Drosophila) in three primary areas: 1) The elucidation of vitamin D3 up-regulated protein 1 (VDUP1) tumor suppressor function during brain development, 包括VDUP1在神经干细胞生物学中的作用, 2) Hedgehog (Hh)依赖性调控VDUP1在细胞增殖中的作用, 包括Hh信号的肿瘤细胞特异性差异如何影响药物治疗策略, 3) Eph受体信号通路的分子表征, which regulate axon guidance, vascular growth, and tumorigenesis. 实验室在这些研究中强调分子遗传学方法, 每个都与临床和翻译相关.
副教授兼研究主任
(518) 694-7238
martha.hass@novimedspecialistclinic.com
Dr. 哈斯的研究整合了合成有机化学, 药物配方及稳定性, biochemical assays, medicinal chemistry, and pharmacology. 她的实验室为学生提供药物合成领域的培训机会, pharmaceutical formulation, topical drug delivery, 以及药物疗效评估. 一个主要的重点领域是用于治疗皮肤疾病的外用药物的合成和活性. One group of novel co-drugs is designed to replenish natural antioxidants in the skin for enhanced and extended photoprotection relative to existing topical products. Other topical agents under development utilize the co-drug approach to target hyperproliferation of keratinocytes and inflammation associated with psoriasis.
Assistant Professor
(518) 694-7175
kideok.jin@novimedspecialistclinic.com
About 70% of estrogen receptor (ER) positive breast cancers have a significantly reduced risk of invasive breast cancer through the use of various endocrine therapies. 尽管他莫昔芬和芳香酶抑制剂具有相对安全性和显著的抗肿瘤和化学预防活性, 许多最初有反应的乳腺肿瘤会产生耐药性并最终复发. My current research is to investigate the secretome leading to the endocrine resistance in crosstalk between endocrine resistant breast cancer and tumor microenvironment. The long-term mission of my laboratory is to understand the steps of the endocrine resistant process in order to develop therapeutic approaches to prevent and treat endocrine resistant breast cancer effectively. The ultimate goal of my research is to bring therapies into the clinic that will improve the survival of metastatic breast cancer patients.
Assistant Professor
(518) 694-7332
timothy.larocca@novimedspecialistclinic.com
Dr. LaRocca的研究兴趣主要在于真核细胞程序性死亡(PCD)的机制. 这包括细胞凋亡过程, necroptosis, 平衡这两种途径的分子开关. Dr. LaRocca对葡萄糖在驱动PCD中的作用特别感兴趣. He is actively investigating the mechanism of hyperglycemic cell death and its role in the exacerbation of ischemic brain injury (stroke). 他实验室的第二个项目是 这是美国国立卫生研究院资助的一项研究，旨在提高对一种红细胞死亡的认识 称为坏死性上睑下垂并探索影响这一过程的方法. Results from this work could one day lead to improved treatments for patients suffering from bacterial blood infections and other blood related disorders.
Professor
(518) 694-7168
meenakshi.malik@novimedspecialistclinic.com
博士的长期研究目标. Malik’s laboratory is to understand the complexities of host pathogen interactions for the development of improved prophylactics and therapeutics against important bacterial infections. She has a 由美国国立卫生研究院提供为期三年的资助 研究土拉菌的致病机制, a类生物威胁剂在免疫细胞内存活并抑制保护性免疫反应. A second area of focus is investigating the molecular mechanisms leading to the development of antibiotic resistance in methicillin resistant Staphylococcus aureus (MRSA) strains. 点击下面的PubMed链接 在博士进行的研究项目的附加信息. Malik's lab.
Associate Professor
(518) 694-7883
marcel.musteata@novimedspecialistclinic.com
Dr. Musteata的研究兴趣包括微型分析技术的发展
药代动力学研究和治疗药物监测, 以创造个性化治疗为目的
集化学分析、决策和给药于一体的设备.
Assistant Professor
(518) 694-7343
manish.shah@novimedspecialistclinic.com
Work in Dr. 沙阿的实验室涉及结构生物学. He is currently investigating genetic polymorphisms in drug metabolizing Cytochrome P450 (CYP) enzymes using structural and biophysical methods. CYP是药物代谢的主要酶家族, and single nucleotide polymorphisms with amino acid substitutions are important contributors to interindividual variability in drug response. In brief, recombinant protein expression and purification are carried out in the laboratory in order to produce the quantities of CYP protein necessary for crystallization. 晶体学数据是远程收集的, 然后利用计算工具阐明蛋白质的三维结构.
Assistant Professor
(518) 694-7116
binshan.shi@novimedspecialistclinic.com
Dr. Shi’s research interests are mainly focused on understanding the molecular basis of disease pathogenesis by using advanced molecular biology, virology, molecular genetics, 以及生物信息学方法. 他的实验室使用的方法包括a) HIV-1感染分子克隆, recombinant virus, and reporter gene technologies to study HIV phenotypes such as infection and replication; b) HIV-1 single genome amplification, 测序和生物信息学工具，以了解基因型变化及其与疾病进展的关系. 博士的另一个主要兴趣领域. Shi的实验室设计和开发用于检测传染病的诊断分析, 监测疾病进展, and managing treatments.
Assistant Professor
(518) 694-7368
vir.singh@novimedspecialistclinic.com
Dr. Singh在研究与HIV发病机制相关的分子机制方面有着广泛的科学背景, genomic imprinting, 分子生物学和小鼠疾病模型. Dr. Singh’s research interests include investigating the underlying molecular mechanisms involved in- i) HIV associated neurological disorder, ii) HIV latency, 病毒感染诱发发育缺陷. Currently, Dr. 辛格的实验室专注于研究NIH HIV/AIDS高优先级研究课题下的两个项目. Project 1: To investigate the consequences of HIV (Human Immunodeficiency Virus) mediated downregulation of Sonic hedgehog (Shh) signaling on brain homeostasis with specific focus on aberrant communication between astrocytes and other brain-resident cells (brain endothelial cells, pericytes, microglia and neurons). Project 2: To characterize select noncoding RNAs for their potential to establish HIV latency via- i) mediating Interferon signaling, ii)通过表观遗传机制调节HIV基因组的表达. Successful completion of these studies will identify novel targets to alleviate HIV pathogenesis as well as pave the way towards HIV cure.
Assistant Professor
(518) 694-7110
eric.yager@novimedspecialistclinic.com
Research in Dr. Yager的实验室致力于了解人体在流感感染期间是如何调节炎症反应的. Recent studies have established a critical role for the multi-protein cytosolic NLPR3 inflammasome complex in host defense and pathophysiology during flu infection. Specifically, Dr. Yager and his team are investigating how NLRP3 inflammasome activation and resultant inflammatory cytokine secretion are regulated on a molecular level to favor host protection over immunopathology. Other areas of research include the identification of novel targets for the development of new anti-viral drugs to combat flu infection and the role of viral-induced inflammation in the etiology and pathogenesis of autism spectrum disorder.
Associate Professor
(518) 694-7895
haian.zheng@novimedspecialistclinic.com
Dr. 郑的研究小组对由植物制成的复杂药物产品(CDP)的设计和评估感兴趣, peptides, and proteins from nature. 采用跨学科技术和转化策略来确保药品质量, 阐明作用机制, 评估临床收益和风险. 这些努力有助于加强监管决策，并实现以患者为中心的产品设计. 实验室目前的项目侧重于评估医用大麻产品的风险和效益. This includes studying the effects of botanical and endogenous cannabinoids on the brain and the blood brain interface (BBI) as well as investigating the endocannabinoid system (ECS) on drug delivery barriers.